Many creams, ointments, lotions, and pills are available to treat psoriasis. Vitamin D3 acts mainly on the vitamin D receptor (VDR) to regulate cell growth, differentiation, and immune function as well as calcium and phosphorus metabolism. Calcipotriene was also the first vitamin D3 analog to be used in psoriasis. 11 After the advent of a combination product containing calcipotriene and betamethasone dipropionate ointment, calcipotriene is available as a cream; Calcitriol ointment is approved for the treatment of mild-to-moderate plaque psoriasis in patients aged 18 years or older. The most common clinical variant is plaque-type psoriasis, characterized by erythematous scaly plaques, round or oval, variable in size, frequently located in scalp, lower back, umbilical region, intergluteal cleft, knees, and elbows 1, 5, 6. While mild disease is commonly treated only with topical agents, the use of topical therapy as adjuvant therapy in moderate-to-severe disease may also be helpful and can potentially reduce the amount of phototherapy or systemic agent required to achieve satisfactory disease control. They are available in a wide range of preparations including gel, cream, ointment, foam, lotion, oil and spray, and a new and innovative vehicle (Table 1) 3, 16. Superpotent corticosteroids are mainly used for stubborn, cutaneous plaques or lesions on the palms, soles, and/or scalp 11, 21, 22.
Most psoriasis patients are treated with topicals. Calcipotriene plus betamethasone dipropionate topical suspension for the treatment of mild to moderate psoriasis vulgaris on the body: a randomized, double-blind, vehicle-controlled trial. 11 The calcipotriene/betamethasone dipropionate two-compound scalp formulation has been shown to be safe and effective in the treatment of scalp psoriasis over 8 weeks, but the patients studied were mainly White and non-Hispanic. Psoriasis: one year data from Phase III study evaluating oral Otezla (apremilast) or injectable etanercept versus placebo Source: Dermatology News From Medical News Today 2015. 11 The calcipotriene/betamethasone dipropionate two-compound scalp formulation has been shown to be safe and effective in the treatment of scalp psoriasis over 8 weeks, but the patients studied were mainly White and non-Hispanic. This study will look into how topical treatment with synthetic Vitamin D3, calcipotriene ointment, used as standard of care, works in patients with morphea.
First-line therapy which includes traditional topical therapies – eg, corticosteroids, vitamin D analogues, dithranol and tar preparations. Vitamin D analogues, usually calcipotriol (eg, Dovonex), are used for longer-term treatment. Patients need to be shown how to apply creams carefully to minimise side-effects (skin irritation and temporary skin staining). Plaque psoriasis can appear on any skin surface, although the knees, elbows, scalp, trunk and nails are the most common locations. Chronic plaque psoriasis, the most common form of psoriasis, is a papulosquamous disease defined by erythematous plaques with a silvery scale. (Dovonex) are the mainstays of topical therapy and, when used together, they may work better than either agent alone. 5 Immunomodulatory drugs, which target the mechanism just described, offer novel treatment options for psoriasis.5 These drugs, also known as biologics, are discussed later.
Chronic Plaque Psoriasis. Symptoms, Causes And Treatment
Eligible patients with psoriasis vulgaris (PV) were enrolled into a randomized comparison in which all subjects received topical sequential therapy and PSORI-CM01 or placebo for 12 weeks. Oral PSORI-CM01 combined with topical sequential treatment showed a smaller recurrence rate (P 0. We designed a run-in period before enrollment and used urea ointment and cetirizine hydrochloride as rescue medicine when skin itchiness affected the patients’ QOL during the whole study. Calcipotriene topical is used to treat plaque psoriasis (psoriasis with scaly patches). In humans, the natural supply of vitamin D depends mainly on exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol to vitamin D3 (cholecalciferol) in the skin. Dovonex (calcipotriene ointment), 0.005, is indicated for the treatment of plaque psoriasis in adults. Daivonex Skin 30 gm Cream Cream, 15.84. Given that the adverse effects associated with systemic therapies are mostly dose dependent, the short duration of these RCTs is unlikely to detect the most critical adverse effects of treatment. 005 and various systemic therapies in the treatment of plaque-type psoriasis vulgaris: review of the literature and results of a survey sent to 100 dermatologists.