OBJECTIVES: To investigate the association between psoriasis and the metabolic syndrome within a large population-based cohort by age and sex. This study suggests age and sex variations in the risk of metabolic syndrome among individuals with psoriasis. Psoriasis is associated with metabolic syndrome and the association increases with increasing disease severity. Coronary Heart Disease in a Hospital-Based Population in Japan. The purpose of this study was to investigate the association between psoriasis and CHD in a hospital-based population in Japan.
Previous studies have suggested a link between psoriasis, a common inflammatory disorder, and individual components of the metabolic syndrome, such as obesity, hypertension, diabetes, and dyslipidemia. However, data on the association between psoriasis and the metabolic syndrome defined by a standard definition12 are scarce,13 as reflected in a recent review. To investigate the association between psoriasis and the metabolic syndrome within a large population-based cohort by age and sex. Since then, multiple population-based studies have suggested an association between these two diseases 7, 11 13. Results from a large population-based study showed an increased relative risk of myocardial infarction (MI) especially in young patients with severe psoriasis 1, 14, 15.
Is psoriasis an independent risk factor for coronary artery disease? OBJECTIVES: To investigate the association between psoriasis and the metabolic syndrome within a large population-based cohort by age and sex. The age- and sex-adjusted odds risk of CVD showed no significant difference between patients with RA and those with PsA 25. In 50 patients with PsA without cardiovascular risk factors or clinically evident CVD, FMD was found significantly lower in patients with PsA compared with 50 matched healthy controls, indicating endothelial dysfunction in PsA as a potential basis for the association between PsA and atherosclerosis 28. There are two studies investigating the prevalence of metabolic syndrome in patients with PsA 44, 48. Kremers, Time trends in epidemiology and characteristics of psoriatic arthritis over 3 decades: a population-based study, Journal of Rheumatology, vol.
Participants with a diagnosis of chronic inflammatory disease were matched on age, sex, and family practice with up to 2 controls randomly sampled from all patients in the CPRD who were never diagnosed with a chronic inflammatory disorder. This nationwide, population-based cohort study was conducted using the Taiwan National Health Insurance Research Database. Under the hypothesis that the use of HCQ is associated with a reduced likelihood of diabetes mellitus, this nationwide population-based study was conducted to examine the association of HCQ therapy with incident diabetes mellitus risk in SLE patients. The relationship between age, sex, drug treatment, co-morbidities and diabetes mellitus risk was evaluated between HCQ users with cumulative doses 129 g and 129 g. The association between psoriasis and diabetes could be explained considering several factors including a common genetic background, the high prevalence of metabolic risk factors for diabetes in patients with psoriasis as well as unhealthy life-styles such heavy drinking, over-eating and sedentary, which are common in patients with psoriasis. Patients with moderate to severe psoriasis have an increased prevalence of the metabolic syndrome that is a cluster of metabolic disorders including abdominal obesity, impaired fasting glucose/diabetes, dyslipidaemia and hypertension 13. Increased chemerin and leptin and reduced adiponectin serum have been reported in patients with psoriasis compared to age, sex and BMI matched controls. Metformin use and survival from lung cancer: A population-based cohort study. Metabolic syndrome in relation to Barrett’s esophagus and esophageal adenocarcinoma: Results from a large population-based case-control study in the Clinical Practice Research Datalink. Epidemiology of fractures in the United Kingdom 1988-2012: Variation with age, sex, geography, ethnicity and socioeconomic status. No association between exacerbation frequency and stroke in patients with COPD. We investigated the association between serum uric acid and risk of diabetes in the Rotterdam Study, a large population-based, prospective cohort study among subjects aged 55 years and older. Important comorbidities are psoriatic arthritis, metabolic syndrome, Crohn’s disease, depression, and cancer. In addition to a relationship between psoriasis and elevated blood glucose and blood pressure in the context of metabolic syndrome, observational studies have detected independent associations between psoriasis and hypertension and diabetes. Another large, population-based case-control study found that the prevalence of COPD was significantly higher in patients with psoriasis (5.
Chronic Inflammatory Disorders And Risk Of Type 2 Diabetes Mellitus, Coronary Heart Disease, And Stroke
The Inflammation Link: Association between psoriasis, diabetes mellitus, and atherosclerosis – A case-control study(JAAD 56: 629-634,April 2007) Background Previous reports demonstrated an association between psoriasis and other diseases including heart failure and diabetes mellitus.